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Starting patients on Aspaveli

Starting patients on Aspaveli

Transitioning off C5i treatment
  • Administer Aspaveli twice-weekly in addition to the patient’s current dose of C5i treatment for the first 4 weeks1
  • After 4 weeks of concomitant therapy, discontinue C5i treatment and start Aspaveli monotherapy for the duration of therapy1
Dose adjusments
  • For LDH levels greater than 2x the ULN, adjust the dosing regimen to 1080 mg every 3 days1
  • In the event of a dose increase, monitor LDH twice-weekly for at least 4 weeks1
Missed doses
  • Administer Aspaveli as soon as possible after a missed dose. Resume the regular dosing schedule following administration of the missed dose1

C5i=complement 5 inhibitor; LDH=lactate dehydrogenase; ULN=upper limit of normal.

Reference: 1. Aspaveli (pegcetacoplan) Summary of Product Characteristics. 2021.