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See a new generation of Ci treatment

See a new generation of Ci treatment

Aspaveli is the first and only C3i, addressing the complete disease mechanism of PNH1

Aspaveli brings control upstream of C5

C3=complement 3; C5=complement 5; C3i=complement 3 inhibitor; Ci=complement inhibitor; EVH=extravascular haemolysis; IVH=intravascular haemolysis; PNH=paroxysmal nocturnal haemoglobinuria.

References: 1. Aspaveli (pegcetacoplan) Summary of Product Characteristics. 2021. 2. Risitano AM, Marotta S, Ricci P, et al. Anti-complement treatment for paroxysmal nocturnal hemoglobinuria: time for proximal complement inhibition? A position paper from the SAAWP of the EBMT. Front Immunol. 2019;10:1157. 3. Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina L. Complement system part II: role in immunity. Front Immunol. 2015;6:257.